The Matheniko Wildlife Reserve is a conservation area in the Karamoja sub region of northeastern Uganda. It is the fifth most-threatened conservation protected area in Uganda.

Location

Matheniko is a part of the corridor of protected areas in Karamoja that stretches from Kidepo National Park down through Bokora and Pian Upe Wildlife Reserves. The Reserve's northeastern boundary is also the Uganda-Kenya border.

This game reserve currently harbors a few species of wildlife though it’s not so busy compared to the rest. The Game reserve has nice specie of vegetation despite its location. The Uganda Wildlife Authority has put a lot of emphasis on developing the tourism infrastructure of the game reserve in the past years. A few years ago, bidders were sought in a campaign to raise funds for constructing an accommodation facility at the Game Reserve.